Satoshi's Wireless Weblog: User Interface is an Art: Harmony Remote. Satoshi has discovered this. BTW, the manufacturer site is "HarmonyRemote.com":http://www.harmonyremote.com/. "Ludwig":http://www.theludwigs.com thinks it is great idea and his family actually would use it.
The heart of the idea is to be activity based and to guess the likely activities from the devices that you have (e.g., if you have an AVR, TV and DVD, I bet you'll want to watch a DVD, by turning on the AVR, the TV, the DVD and then hitting play). Cost is $300, so pretty high given that you can get a color Pronto for $600, but I bet volumes are small.
The best source of information is at "Remote Central":http://remotecentral.com/cgi-bin/mboard/rc-harmony/list.cgi. Hmmm. I'll have to get one. I've been using the Color Pronto for home, but these are expensive. Great screen though.